Poly(ADP-ribose) polymerase (PARP), also termed poly(ADP-ribose) synthetase (PARS), is a nuclear enzyme with a wide range of functions including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, Dr. Nathan Berger and colleagues proposed a novel role for this enzyme, mediating a suicidal mechanism triggered by DNA strand breakage. As summarized in 1995 by Berger, “when DNA strand breaks are extensive or when breaks fail to be repaired, the stimulus for activation of poly(ADP-ribose) persists and the activated enzyme is capable of totally consuming cellular pools of NAD.
CONTENTS
Introduction
1. Nitric Oxide and Poly(ADP-Ribose) Polymerase in Neuronal Cell Death
2. Role of Poly(ADP-Ribose) Polymerase Mediating Acute and Chronic Neuronal Injury and Neurodegeneration
3. Importance of Poly(ADP-Ribose) Polymerase Activation in Myocardial Reperfusion Injury
4. Role of Poly(ADP-Ribose) Polymerase Activation in Inflammation
5. Poly(ADP-Ribose) Polymerase Activation and the Pathogenesis of Circulatory Shock
6. Role of Poly(ADP-Ribose) Polymerase in the Pathogenesis of Pancreatic Islet Cell Death and Type 1 Diabetes
7. Poly(ADP-Ribose) Polymerase in the Immune System: Focus on Reactive Nitrogen Intermediates and Cell Death
8. Protective Effect of Poly(ADP-Ribose) Polymerase Inhibitors against Cell Damage Induced by Antiviral and Anticancer Drugs
9. Involvement of Poly(ADP-Ribose) Polymerase in the Cellular Response to DNA Damage
10. Role of Poly(ADP-Ribose) Polymerase in Apoptosis
11. Poly(ADP-Ribose) Polymerase is an Active Participant in Programmed Cell Death and Maintenance of Genomic Stability
12. Pleiotropic Roles of Poly(ADP-Ribosyl)ation of DNA-Binding Proteins
13. Poly(ADP-Ribose) Polymerase Inhibition by Genetic and Pharmacological Means
14. Determination of Poly(ADP-Ribose) Polymerase Activation and Cleavage during Cell Death
15. Isoforms of Poly(ADP-Ribose) Polymerase: Potential Roles in Cell Death
CONTENTS
Introduction
1. Nitric Oxide and Poly(ADP-Ribose) Polymerase in Neuronal Cell Death
2. Role of Poly(ADP-Ribose) Polymerase Mediating Acute and Chronic Neuronal Injury and Neurodegeneration
3. Importance of Poly(ADP-Ribose) Polymerase Activation in Myocardial Reperfusion Injury
4. Role of Poly(ADP-Ribose) Polymerase Activation in Inflammation
5. Poly(ADP-Ribose) Polymerase Activation and the Pathogenesis of Circulatory Shock
6. Role of Poly(ADP-Ribose) Polymerase in the Pathogenesis of Pancreatic Islet Cell Death and Type 1 Diabetes
7. Poly(ADP-Ribose) Polymerase in the Immune System: Focus on Reactive Nitrogen Intermediates and Cell Death
8. Protective Effect of Poly(ADP-Ribose) Polymerase Inhibitors against Cell Damage Induced by Antiviral and Anticancer Drugs
9. Involvement of Poly(ADP-Ribose) Polymerase in the Cellular Response to DNA Damage
10. Role of Poly(ADP-Ribose) Polymerase in Apoptosis
11. Poly(ADP-Ribose) Polymerase is an Active Participant in Programmed Cell Death and Maintenance of Genomic Stability
12. Pleiotropic Roles of Poly(ADP-Ribosyl)ation of DNA-Binding Proteins
13. Poly(ADP-Ribose) Polymerase Inhibition by Genetic and Pharmacological Means
14. Determination of Poly(ADP-Ribose) Polymerase Activation and Cleavage during Cell Death
15. Isoforms of Poly(ADP-Ribose) Polymerase: Potential Roles in Cell Death
Páginas : 352
Peso : 7mb.
Formato : PDF.
Edición : Primera
Año de Publicación :2000
ISBN : 9780849322679
Editorial : CRC Press
Autor: Csaba Szabo, Semmelweis University, Budapest, Hungary
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